Chemistry pharmacology and clinical applications of proteinase inhibitors nathan back home worldcat home about worldcat help search search for library items search for lists search for annals of the new york academy of sciences v 146 art 2 responsibility. Ludwig chemistry pharmacology clinical applications of proteinase inhibitors 1968 academy of sciences new york 509 510 9 n thumb von p weidinger k atefi intraartikulare therapie mit einem proteinasenhemmer wien z med 51 1970 7 11 10. Though designed to target only the hiv protease hiv protease inhibitors pis induce toxicities in patients such as insulin resistance and lipodystrophy that suggest that pis have other targets in mammalian cells akt controls insulin signaling and is an important target in cancer but no akt inhibitors are approved as cancer therapeutics
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