Tuberculosis tb is a serious public health problem worldwide its situation is worsened by the presence of multidrug resistant mdr strains of mycobacterium tuberculosis the causative agent of the diseasein recent years even more serious forms of drug resistance have been reported. To investigate transmission of drug resistant strains of mycobacterium tuberculosis in tunisia we performed whole genome sequencing on 46 multidrug resistant strains isolated during 2012 2016 core genome multilocus sequence typing grouped 30 strains 652 into 3 clusters indicating extensive recent transmission and haarlem clone predominance. Detection of all forms of drug resistance in tb is a key factor to reduce and contain the spread of these resistant strains a better knowledge of the mechanisms of action of anti tb drugs and the development of drug resistance will allow identifying new drug targets and better ways to detect drug resistance. Drug resistance in mycobacterium tuberculosis from microbewiki the student edited microbiology resource jump to navigation search this student page has not been curated tuberculosis tb is a potentially deadly disease caused by pathogenic bacteria usually mycobacterium tuberculosis. Multi drug resistant tuberculosis mdr tb is a form of tuberculosis tb infection caused by bacteria that are resistant to treatment with at least two of the most powerful first line anti tb medications drugs isoniazid and rifampin some forms of tb are also resistant to second line medications and are called extensively drug resistant tb
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