The evolution of clinical research traverses a long and fascinating journey from the first recorded trial of legumes in biblical times to the first randomized controlled of trial of streptomycin in 1946 the history of clinical trial covers a wide variety of challenges scientific ethical and regulatory. Research case country location year summary psychosurgery 1880s psychosurgery also called neurosurgery for mental disorder has a long historyduring the 1960s and 1970s it became the subject of increasing public concern and debate culminating in the us with congressional hearings. World medical association helsinki declaration ethical principles for research on human subjects revised several times most recently in 2001 1964 the us surgeon generals office issues its first of several reports on health problems related to smoking 1966. The indian council of medical research brought out the policy statement on ethical considerations involved in research on human subjects in 1980 and revised these guidelines in 2000 as the ethical guidelines for biomedical research on human subjects since then it has been revised and the latest version has been published in 2006. The office of history national institutes of health exists to advance historical understanding of biomedical research within the nih and the world through preserving records of significant nih achievements innovative exhibits educational programs and training researchers from multiple disciplines the office of history explores the past to enhance present understanding of the health
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