Other models such as the chick embryo chorioallantoic membrane cam assay are therefore an attractive alternative cam assays have been widely used to study angiogenesis and tumor invasion of colorectal prostate and brain cancers however there have been limited studies that have used cam assays to assess ovarian cancer invasion and . D ribatti m bertossi b nico a vacca r ria a riva l roncali m prestarole of basic fibroblast growth factor in the formation of the capillary plexus in the chick embryo chorioallantoic membrane an in situ hybridization immunohistochemical and ultrastructural study. Since their introduction almost a century ago chick embryo model systems involving the technique of chorioallantoic grafting have proved invaluable in the in vivo studies of tumor development and angiogenesis and tumor cell dissemination the ability of the chick embryos chorioallantoic membrane . The chick embryo chorioallantoic membrane in the study of angiogenesis and metastasis angiogenic dependent tumor growth and metastasis in vivo angiogenesis assays examine the entire spectrum of molecular and cellu ribatti and vacca 1999 and the chick embryo chorioallantoic membrane cam several models have been introduced . Angiogenesis is the process of formation of new blood vessels from pre existing vessels or endothelial cell progenitors it plays a crucial role in tumor growth and metastasis tumor angiogenesis have been widely studied as an important target for suppressing tumor growth and metastasis here we describe an in vivo chick embryo chorioallantoic membrane cam model
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